BCR-ABL1 Mbcr and Mbcr Screening Kit, Temperature Storage 2-8 Degree Celcius, Brand Mylab, Test Time 5 Minutes

Bcr, Abl1 and cancer oncoscreen bcr/abl1 kIt functions as a research tool utilizing multiplex real, Time quantitative rt, Pcr to provide simultaneous detection and quantification of bcr/abl1 fusion transcripts b2a2 /b3a3, Or e1a2, And abl1 an endogenous control . The cr/abl1 kit works seamlessly with various commercially available real, Time pcr systems. Themultiplexed format of the bcr/abl1 kit reduces reflex testing by providing quantitation within the three options predominant bcr/abl1 fusion transcripts. Approximately 95% of cases of chronic myeloid leukemia cml and about 35% of acute lymphoblastic leukemia all are linked to the presence of a t 9, 22 q34, Q11 chromosomal translocation philadelphia chromosome, Ph . This results in creation of an oncogenic fusion gene between abl proto, Oncogene and bcr on chromosomes 9 and 22, Respectively. The breakpoint on chromosome 22 occurs between exons 12 and 16 of the while the, Bcr gene breakpoint on chromosome 9 mostly occurs between exons 1 and 2 of the abl gene. The major transcripts are called b2a2 and b3a2, Which encode for a constitutively active chimeric tyrosine kinase of 210kda p210 . The breakpoint on chromosome 22 takes place within the first intron of the bcr gene together with the breakpoint on chromosome 9 occurs between exons 1 and 2 of the abl gene e1a2 . This joins the minor transcripts exon 1 of bcr to exon 2 of abl, Creating a 190 kda fusion protein with a constitutively active kinase domain. Kit features standardized quantitative protocol for control and fusion gene transcriptsoptimal quality control to assure high sensitivityeasy streamlined process with pre-configured tools solutions for clinical laboratory serving customers directly testssimple configuration for reactions and data interpretationone, Step quantitative detection no need to perform separate cdna synthesis and qpcrresults aligned with international control standards The kit comes complete with minimal contamination risk and eliminates the demand for post-PCR processing product handling multiplexed control and target genes evaluated within the same reaction comprises every one of the reagent required to perform rnakit contents reagents required for cdna synthesis and pcr amplification/detection validated reaction controls plastic wares for the screening kitorder information #productcat. No. Reaction size/kit1oncoscreen bcr, Abl1 mbcr quantitative pcr kitobbq25252oncoscreen bcr, Abl1 mbcr quantitative pcr kitobbq50503oncoscreen bcr, Abl mbcr and mbcr quantitative pcr kitobbeq25254oncoscreen bcr, Abl1 mbcr and mbcr quantitative pcr kitobbeq50505oncoscreen bcr, Abl1 mbcr and mbcr quantitative pcr kitobbeq100100